When our doctors perform the in vitro fertilization process, they extract mature eggs from the female and fertilize the egg with sperm in our embryology lab. After the egg is properly fertilized it is then transferred back into the uterus.
IVF may be a first line treatment for women with tubal disease, those of advanced age, ovarian failure, or unexplained infertility. Women with low ovarian reserve or ovarian failure, can use an egg donor during the IVF process. Intracytoplasmic sperm injection (ICSI) is also often used to increase the chances of IVF success.
Minimal Stimulation IVF
In contrast to traditional IVF with the goal of producing 10-20 mature eggs and possibly having embryos available to freeze, Minimal Stimulation IVF can be done at a lower cost, utilizing less medication and monitoring.
In Minimal Stimulation IVF, oral medications like Clomid or Femara are combined with lower doses of the injectable hormones traditionally used in IVF. As a result, less intensive monitoring is required.
Minimal Stimulation IVF also puts the patient at a lower risk of Ovarian Hyperstimulation Syndrome, a complication more commonly associated with traditional IVF. Although Minimal Stimulation IVF usually results in a lower cost cycle with less medications and intensive monitoring, it also typically results in fewer available embryos. Most patients who do Minimal Stimulation IVF do not have embryos to freeze and pregnancy rates are typically lower than with traditional IVF. Minimal stimulation can offer a cost- effective option for select couples who want a cycle with less monitoring, lower medication costs and do not want to freeze embryos.
INVOcell IVF Option
For a limited time, RCC is offering a discounted IVF option (starting at $4,900 not including the initial exam, medications, anesthesia or ICSI). Unlike traditional IVF, incubation takes place within the body instead of in a laboratory setting. Medication is used to stimulate the production of eggs (oocytes) by the ovaries. The provider monitors through ultrasounds and blood tests to determine when the eggs are ready for retrieval. Using an Ovum Aspiration Needle with the guidance of ultrasound, the physician retrieves the eggs from the ovaries before ovulation.
At this point in a traditional IVF cycle, the eggs would then be taken to be inseminated in the lab and placed in an incubator. However, with INVOcell, after retrieval, the eggs are evaluated for quality and are then inserted into an INVOcell device, along with sperm, and are placed into the upper part of the vagina where they incubate for 3-6 days so they can grow and become embryos. After incubation, the INVOcell device is retrieved from the vagina, the embryologist evaluates the embryos, and an embryo is selected to be transferred into the uterus. Excess embryos may be frozen and stored for subsequent cycles.
This technology has resulted in similar pregnancy rates in tests elsewhere, however, RCC cannot guarantee the same pregnancy and success rates using INVOcell vs traditional IVF treatments.
Is INVOcell right for me?
RCC physicians review both partners’ medical histories and complete laboratory and diagnostic testing to properly diagnose possible factors causing infertility. Patients interested in INVOcell should speak with their physician to determine if they qualify medically and whether INVOcell or traditional IVF would be the better option to offer the best chances for a successful pregnancy.
What are the advantages of INVOcell over traditional IVF?
INVOcell is an IVF option for patients who medically qualify. When comparing data to conventional stimulation IVF, INVOcell has similar pregnancy rates. Good quality embryos are produced in a way that requires much less physical handling of the embryo, in a natural environment. The INVOcell process reduces much of the lab work that is required in maintaining a healthy environment for the embryo.
What are the benefits of doing traditional IVF rather than INVOcell?
- Traditional IVF is the better option for patients likely to produce a large number of mature eggs.
Traditional IVF may be a better option to optimally manage a large number of embryos, whereas INVOcell is limited in its capacity to do so. If patients are hoping to have several embryos to choose from and store for future use, traditional IVF may be a better treatment option.
- Traditional IVF allows the embryologist to verify fertilization was normal.
With INVOcell, the embryologist is not able to verify fertilization was normal. If an embryo has an irregular fertilization, it can still appear to be a normal embryo at day five. However, if this embryo is actually abnormal and is transferred, it will most likely result in a failure to implant or miscarriage. With traditional IVF, the embryologist can monitor fertilization and ensure any embryo being transferred into the uterus fertilized normally, increasing the potential to achieve a healthy pregnancy.
- Traditional IVF allows the embryologist to monitor the growth and health of each embryo during incubation.
In rare cases, the embryologist and physician feel the need to transfer the embryo at day 3 rather than day 5. This generally happens when there are indications the embryo may not survive to day 5. While pregnancy rates are lower when this occurs, it may provide the embryo the opportunity to implant and potentially result in a successful pregnancy. This monitoring can only occur with traditional IVF.
- Preimplantation Genetic Diagnosis (PGD) and Preimplantation Genetic Screening (PGS) are only options with traditional IVF.
Patients wanting to biopsy and test their embryos for genetic reasons are only able to do so using traditional IVF.
INVOcell is a new technology that RCC offers for qualified and appropriate candidates as a low-cost IVF option. It is very important to discuss the pros and cons of choosing INVOcell vs traditional IVF with your physician so an appropriate treatment plan can be created to allow for the best possible results in achieving a pregnancy.
Collect Mature Eggs and Sperm
Under the direction of a specialist
Fertilization of Egg
Leading to the formation of embryos
Transfer of Embryos
Fertilized eggs are transferred back into the uterus for implantation.
IVF Success Rates
Reproductive Care Center (RCC) is committed to accurate and honest portrayal of IVF success rates. We report our success rates to the Society of Assisted Reproductive Technology (SART) and the Centers for Disease Control. SART oversees data collection under strict guidelines thus insuring accuracy.
All reputable IVF centers report their IVF success rates to SART. If a center does not report to SART, there is no control over how their data is collected and presented. You may see a non-reporting clinic claiming high IVF success rates on the Internet, which is misleading if the number of patients was small and they were in their twenties. SART membership should be one of your first criteria for selecting an IVF center.
The most recent published SART success rate data (2016) is below. For more details please visit our SART website.
|Number of patients||233||51||18||5||2|
|Triplets or more||.4%||0%||0/18||0/5||0/2|
|Number of cycle starts||312||81||39||15||11|
|Triplets or more||0.3%||0%||0%||0/15||0/11|
|Number of cycle starts||312||81||39||15||11|
|Triplets or more||0.3%||0%||0%||0/15||0/11|
|Number of thaw procedures||106||40||13||1||1|
|Triplets or more||0%||0%||0/13||0/1||0/1|
Intracytoplasmic Sperm Injection (ICSI)
The introduction of ICSI revolutionized the treatment of male infertility allowing men with as few as one sperm to father genetically related children. Prior to ICSI, the only option for patients with moderate to severe male infertility was to use a sperm donor, donor embryos or adoption.
ICSI is conducted in conjunction with an IVF cycle. Once the follicles mature, the eggs are retrieved transvaginally using ultrasound guidance. Once retrieved they are transferred to the embryology laboratory where the eggs are separated from the follicular fluid.
Assisted hatching is a procedure designed to improve embryonic implantation rates. It is performed in conjunction with an in vitro fertilization cycle (IVF) , where an embryo is created as a result of FSH stimulation, egg retrieval, and fertilization.
In an IVF cycle, embryos are cultured until mature and ready for transfer, which is usually from three to six days. As the embryos develop, they pass through several developmental stages including blastocyst formation. (We typically refer to day 5 embryos as blastocysts, however, embryos may form blastocysts before or after 5 days.)
Preimplantation Genetic Diagnosis – Screening Genetic Diseases
PGD, was made possible by advances in in vitro fertilization (IVF) which revolutionized infertility treatment and opened the door for many new and exciting technologies. These technologies include intracytoplasmic sperm injection (ICSI), which gave “infertile males” new hope for creating genetically related children.